Exit-strategies in Natalizumab-treated RRMS at high risk of progressive multifocal leukoencephalopathy: A multicentre comparison study
نویسندگان
چکیده
The main aim of the study is to evaluate efficacy and safety profile Ocrelizumab (OCR), Rituximab (RTX), Cladribine (CLA), employed as Natalizumab (NTZ) exit-strategies in Relapsing-Remitting Multiple Sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML).
منابع مشابه
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab.
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection of the central nervous system, developed during treatment with interferon beta-1a and a selective adhesion-molecule blocker, natalizumab. The first PML lesion apparent on magnetic resonance imaging was indistinguishable from a multiple s...
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the brief reports on natalizumab were referred to biogen idec, the manufacturer, which offers the following response: After learning of one confirmed and one suspected case of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, Biogen Idec and Elan quickly notified the Food and Drug Administration (FDA) and other regulatory authorities. We worked closely with ...
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BACKGROUND Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients. METHODS We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, C...
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In this issue of the Journal, there are reports describing in detail three patients in whom progressive multifocal leukoencephalopathy (PML) developed during treatment with natalizumab, a humanized monoclonal antibody against a 4 integrins. 1-3 These patients were among 3000 who had participated in clinical trials of natalizumab for the treatment of multiple sclerosis or Crohn’s disease. PML is...
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OBJECTIVE To describe the clinical, radiological, and histopathological features of a fatal case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple sclerosis treated with natalizumab. We will use this case to review PML risk stratification and diagnosis. DESIGN Case report. SETTING Tertiary referral center hospitalized care. PATIENT A 55-year-old, JC virus (JCV...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2021
ISSN: ['0022-510X', '1878-5883']
DOI: https://doi.org/10.1016/j.jns.2021.117769